THE SCIENTIFIC MARKET
Cortical Bone Mechanics Technology™ (CBMT)
Unprecedented Research Opportunities
A bone fractures when a force imposed on it is greater than the bone’s strength. The strength of a bone is determined by its mechanical properties. Until now, a major hindrance to clinical research on bone strength has been the lack of any commercially available, non-invasive technique for measuring the mechanical properties of bone in living human subjects. AEIOU’s SI-001 CBMT system is the first scientific instrument to make accurate, direct, functional measurements of the mechanical properties of cortical bone, and, thereby, accurate estimates of the strength of cortical bone in living people. Thus, this new instrument opens opportunities for unprecedented research investigating factors affecting cortical bone mechanics. Such investigations include:
Observational studies comparing cortical bone mechanics in various demographic groups, and monitoring changes in cortical bone mechanics over time; and
Controlled experiments investigating local and systemic effects on cortical bone mechanics.
AEIOU’s CBMT Scientific Instrument SI-001 enables investigators to compare mechanical properties of cortical bone in demographic groups differing in
- Age, sex, race, ethnicity, body size, occupation, physical activity, disease etc.
SI-1 also enables investigators to conduct novel prospective observational studies of changes in cortical bone mechanics over time during:
- Adolescence, post-menopause, athletic training, disease progression etc.
AEIOU Model SI-001 Scientific Instrument.
SI-1 also enables unprecedented controlled experiments (clinical trials) investigating causal influences on cortical bone mechanics. These fall into two categories:
- Investigations into local effects of mechanical loading (i.e., exercise), which may differ in modality, intensity, duration, rest interval etc.
- Investigations into systemic effects of factors affecting cortical bone in the skeleton as a whole, including nutrition and nutraceutical, hormonal and pharmaceutical agents.